Saponin and Sapogenol. XLVIII.1) On the Constituents of the Roots of Glycyrrhiza uralensis Fischer from Northeastern China. (2). Licorice-saponins D3, E2, F3, G2, H2, J2, and K2

Abstract

Following the characterization of licorice-saponins A3 (2), B2 (3), and C2 (4), the chemical structures of licorice-saponins D3 (5), E2 (6), F3 (7), G2 (8), H2 (9), J2 (10), and K2 (11), seven of the ten oleanane-type triterpene oligoglycosides isolated from the air-dried roots of Glycyrrhiza uralensis Fischer collected in the northeastern part of China, were investigated. On the basis of chemical and physicochemical evidence, the structures of licorice-saponins D3, E2, F3, G2, H2, J2, and K2 have been determined to be expressed as 3β-[a-L-rhamnopyranosyl(1→2)-β-D-glucuronopyranosyl(1 →2)-β-D-glucuronopyranosyloxy]-22β-acetoxyolean-12-en-30-oic acid (5), 3-0-[β-D-glucurono-pyranosyl(1 →2)-β-D-glucuronopyranosyl]glabrolide (6), 3-0-[α-L-rhamnopyranosyl(1→2)-β-D-glucuronopyranosyl-(1→2)-β-D-glucuronopyranosyl]-11-deoxoglabrolide (7), 24-hydroxyglycyrrhizin (8), 3-O-[α-D-glucuronopyranosyl-(1→2)-β-D-glucuronopyranosyl]liquiritic acid (9), 24-hydroxy-11-deoxoglycyrrhizin (10), and 3β-[β-D-glucuronopy-ranosyl(1 →2)-β-D-glucuronopyranosyloxy]-24-hydroxyoleana-11,13(18)-dien-30-oic acid (11), respectively. © 1993, The Pharmaceutical Society of Japan. All rights reserved.