Digital Twins in Bioprocess Engineering – Challenges and Possibilities

Abstract

The digitalization of processes is one of the currently dominating topics and missions in both industrial production and scientific research. In biotechnology, these efforts have enormous potential to optimize existing bioprocesses or to develop new bioprocesses for upcoming challenges. In this review, the state-of-art of digitalization in bioprocess engineering is considered, the terms digital twin and digital shadow are characterized, and an outlook on future Lab 4.0 concepts is given.