Synthesis of oligosaccharides of biological importance

Abstract

Syntheses of a variant of myo-inositol-containing compounds are discussed and described, including glycan phosphatidylinositol structures found on various cell surfaces and believed to play important roles in the life cycles of tropical parasites (Trypanosoma and Leishmania) and in the action of insulin, and phosphatidyl inositol phosphates, known signal substances in a number of biological events. The resolution of myo-inositol is performed using camphor acetals and the phosphodiester linkages are introduced using H-phosphonates.