Macrophage metabolism: a wound-healing perspective

Abstract

Macrophages are a critical component of the innate immune response, and compose the first response to perturbations in tissue homeostasis. Their unique ability to dynamically integrate diverse stimuli underlies their important role in the healing response from first insult to re-establishment of tissue homeostasis. While the roles of macrophages in tissue repair have been well-described in vitro and in vivo, the influence of cellular metabolism on macrophage function during tissue repair remains an unexplored area of immunometabolism. In this review, we will explore the unique metabolic requirements of inflammatory and anti-inflammatory macrophages and the potential contribution of macrophage metabolism to each phase of wound healing.