3D Human Esophageal Epithelium Steps Out from hPSCs

Abstract

Human pluripotent stem cell (hPSC)-derived organoids can reveal important principles underlying tissue development. In this issue of Cell Stem Cell, Zhang et al. (2018) and Trisno et al. (2018) establish protocols for generating esophageal epithelial cells and 3D stratified epithelium from hPSCs, revealing roles for key signaling pathways and how they are controlled by critical transcription factors. Human pluripotent stem cell (hPSC)-derived organoids can reveal important principles underlying tissue development. In this issue of Cell Stem Cell, Zhang et al. (2018) and Trisno et al. (2018) establish protocols for generating esophageal epithelial cells and 3D stratified epithelium from hPSCs, revealing roles for key signaling pathways and how they are controlled by critical transcription factors.