Synthesis of Iminosugar Glycosidase Inhibitors Modeled on Siastatin B Directed toward New Agents for Tumor Metastasis and Viral Infection

Abstract

Specific inhibitors of glycosidases are aiding in unraveling how oligosaccharides of glycoconjugates, as the functional domains for carbohydrate-protein interactions, regulate biological functions, and how they produce beneficial pharmaceutical effects in the prevention and treatment of a variety of diseases. This paper describes the progress of the synthesis of iminosugar glycosidase inhibitors, siastatin B analogues toward the rational drug design of D-glucuronic acid and L-iduronic acid-based inhibitors for tumor invasion, and of sialic acid-based inhibitors for the influenza virus sialidase, as well as indicating progress in the development of a new therapeutic and prophylactic treatment for tumor metastasis and influenza infection.