We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model
CITATION STYLE
Petre, I., Mizera, A., Hyder, C. L., Mikhailov, A., Eriksson, J. E., Sistonen, L., & Back, R. J. (2009). A new mathematical model for the heat shock response. Natural Computing Series, (9783540888680), 411–425. https://doi.org/10.1007/978-3-540-88869-7_21
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