The aim of the present study was to quantify both perfusion and extravasation in the prostate to discriminate tumor from healthy tissue, which might be achieved by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a nonspecific low-molecular-weight contrast medium (CM). To determine extravasation as well as tissue perfusion an inversion-prepared dual-contrast sequence employing a parallel acquisition technique (PAT) was designed for interleaved acquisition of T1-weighted images for extravasation measurement and T2*-weighted images for determination of the highly concentrated bolus with a sufficiently high temporal and spatial resolution at an acceptable signal-to-noise ratio. Thirteen patients with proven prostate cancer were examined with the sequence using a combined body-array prostate coil. Before pharmacokinetic evaluation the images were intensity-corrected and, if required, motion-corrected. The pharmacokinetic model used to calculate perfusion, permeability, blood volume, interstitial volume, transit time, and vessel size index included two compartments and a correction of delay and dispersion of the arterial input function. The information provided by the dual-contrast sequence allowed application of a more elaborate model for evaluation and enabled quantification of all parameters. Peripheral prostate tumors were found to differ from peripheral healthy prostate tissue in perfusion (1.38 ml/(min•cm3) vs. 0.23 ml/(min• cm3), P=0.001), blood volume approximately two times higher, 1.9 % vs. 0.7 %; and mean transit time in tumors approximately half that of normal prostate tissue, 2.88±2.30 s vs. 4.88±3.21 s. A inversion-prepared dual-contrast sequence acquiring T1- and T2*-weighted images with sufficient temporal resolution and signal-to-noise ratio was successfully applied in patients with prostate cancer to quantify all pharmacokinetic parameters of inflow and extravasation of a low-molecular-weight inert tracer. © 2009 Springer-Verlag.
CITATION STYLE
Lüdemann, L., Prochnow, D., Franiel, T., Taupitz, M., Rehbein, H., & Beyersdorff, D. (2009). Delay and dispersion correction for simultaneous quantification of perfusion and permeability in the prostate using DCE-MRI with a dual-contrast sequence. In IFMBE Proceedings (Vol. 25, pp. 14–15). Springer Verlag. https://doi.org/10.1007/978-3-642-03879-2_5
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