Metabolic control of ferroptosis in cancer

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Abstract

Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

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Murphy, M. P. (2018). Metabolic control of ferroptosis in cancer. Nature Cell Biology, 20(10), 1104–1105. https://doi.org/10.1038/s41556-018-0209-x

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