Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis

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Abstract

We found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3-O-α-L-(2″,4″-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol 3-O-α-L-(2″-Z-p-coumaroyl-4″-E-p- coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae, Pseudomonas aeruginosa and Serratia marcescens. © 2008 Pharmaceutical Society of Japan.

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Otsuka, N., Liu, M. H., Shiota, S., Ogawa, W., Kuroda, T., Hatano, T., & Tsuchiya, T. (2008). Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis. Biological and Pharmaceutical Bulletin, 31(9), 1794–1797. https://doi.org/10.1248/bpb.31.1794

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