Molecular mechanisms of possible action of phenolic compounds in covid-19 protection and prevention

N/ACitations
Citations of this article
63Readers
Mendeley users who have this article in their library.

Abstract

The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.

Cite

CITATION STYLE

APA

Gligorijevic, N., Radomirovic, M., Nedic, O., Stojadinovic, M., Khulal, U., Stanic-Vucinic, D., & Velickovic, T. C. (2021, November 1). Molecular mechanisms of possible action of phenolic compounds in covid-19 protection and prevention. International Journal of Molecular Sciences. MDPI. https://doi.org/10.3390/ijms222212385

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free