Glutathione deficiency and peripheral metabolism of thyroid hormones during dietary cysteine deprivation in rats

  • Suberville C
  • Higueret P
  • Taruoura D
  • et al.
4Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

1. For a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1·93 g cysteine/kg. 2. The thyroxine (T 4 ) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. Moreover, the extrathyroidal T 4 pool and T 4 disposal rate decreased. 3. Cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (T 3 ). The T 3 distribution space, extrathyroidal pool of T 3 and T 3 disposal rate were diminished. 4. In vitro, deiodination of T 4 in liver homogenate assayed with endogenous glutathione (GSH) demonstrated decreased T 3 production rates in the case of cysteine deficiency. This difference was minimized by the addition of GSH in amounts sufficient to saturate the reaction kinetics. In the light of this finding, GSH is probably involved in the promotion of certain thyroidal problems induced by a cysteine-deficient diet.

Cite

CITATION STYLE

APA

Suberville, C., Higueret, P., Taruoura, D., Garcin, H., & Higueret, D. (1988). Glutathione deficiency and peripheral metabolism of thyroid hormones during dietary cysteine deprivation in rats. British Journal of Nutrition, 59(3), 451–456. https://doi.org/10.1079/bjn19880054

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free