Heparan sulfate in the tumor microenvironment

22Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The biology of tumor cells strictly depends on their microenvironment architecture and composition, which controls the availability of growth factors and signaling molecules. Thus, the network of glycosaminoglycans, proteoglycans, and proteins known as extracellular matrix (ECM) that surrounds the cells plays a central role in the regulation of tumor fate. Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are highly versatile ECM components that bind and regulate the activity of growth factors, cell membrane receptors, and other ECM molecules. These HS binding partners modulate cell adhesion, motility, and proliferation that are processes altered during tumor progression. Modification in the expression and activity of HS, HSPGs, and the respective metabolic enzymes results unavoidably in alteration of tumor cell microenvironment. In this light, the targeting of HS structure and metabolism is potentially a new tool in the treatment of different cancer types.

Cite

CITATION STYLE

APA

Bartolini, B., Caravà, E., Caon, I., Parnigoni, A., Moretto, P., Passi, A., … Karousou, E. (2020). Heparan sulfate in the tumor microenvironment. In Advances in Experimental Medicine and Biology (Vol. 1245, pp. 147–161). Springer. https://doi.org/10.1007/978-3-030-40146-7_7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free