Synthesis and in vitro anti-breast cancer activity of some novel 1,5-benzothiazepine derivatives

Abstract

The title compounds 3a-j, substituted 1,5-benzothiazepines, were synthesized by the condensation of variously substituted chalcones 1 and 2-aminothiophenol 2 via conventional as well as non-conventional inorganic solid support microwave irradiation methods. The non-conventional protocol offers several advantages, such as simple procedure, fast reaction rate, mild reaction conditions and improved yields, compared to conventional methods. The structures of the products 3a-j were established by elemental analysis, FTIR, 1H-NMR, 13C-NMR and mass spectroscopic studies. The synthesized compounds were also evaluated for their cytotoxicity against the human breast cancer cell line MDA-MB-435, with some exhibiting in vitro anti-breast cancer activity.