Antitumor activity of a Brucella abortus preparation

Abstract

Mice injected intraperitoneally with sarcoma 180 cells develop ascites and eventually die. Intraperitoneal injection of a nonviable, aqueous ether extracted Brucella abortus preparation (BRU PEL) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. BRU PEL was not effective if injected after ascites was grossly apparent. BRU PEL was significantly more active than a Corynebacterium parvum preparation administered in the same way.