Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease

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Abstract

Introduction: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. Methods: The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry. Results: Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease. Conclusions: These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.

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de Miranda, M. B., de Melo, A. S., Almeida, M. S., Marinho, S. M., Oliveira Junior, W., & Gomes, Y. de M. (2017). Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease. Revista Da Sociedade Brasileira de Medicina Tropical, 50(5), 689–692. https://doi.org/10.1590/0037-8682-0025-2017

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