Statins in Females

Abstract

Statins have turned out to be widely recommended in the prevention of cardiovascular diseases (CVD) owing to their favorable effect on lipid metabolism and patient survival. Statin treatment is usually all around endured and effective in the prevention and treatment of CVD, irrespective of cholesterol levels. However, studies on statin therapy have reported various adverse effects such as myalgia, myopathy, rhabdomyolysis, and diabetes mellitus. Primary and secondary prevention studies of CVD have been grossly underpowered regarding enrolment of women, limiting the ability to stratify results by sex. In high-risk women, statins reduce coronary events and stroke. For primary prevention, the benefits and risks of statin therapy remain less well defined in women. CVD prevention includes lifestyle modification for all women and medical treatment for those with prevailing CVD risk factors or known disease. It has been proved that statins reduce the rates of cardiovascular events and mortality. Randomized clinical trials suggest that statins are safe in most patients with the previous stroke and reduces the occurrence of coronary adverse events and stroke by ~20%. In populations at high baseline risk of CVD, cardiovascular benefits of statin therapy overweigh the potential risk of increased serum glucose levels.