Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret

9Citations
Citations of this article
27Readers
Mendeley users who have this article in their library.

Abstract

Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N8 strains did not induce mortality and significant respiratory signs after an intranasal challenge in ferrets. However, ferrets intratracheally infected with A/broiler duck/Korea/Buan2/2014 virus showed dose-dependent mortality. Although the Korean H5N8 strains were classified as the HPAI virus, possessing multiple basic amino acids in the cleavage site of the hemagglutinin sequence, they did not produce pathogenesis in ferrets challenged intranasally, similar to the natural infection route. These results could be useful for public health by providing the pathogenic characterization of H5N8 viruses.

Author supplied keywords

Cite

CITATION STYLE

APA

Kim, H. M., Kim, C. K., Lee, N. J., Chu, H., Kang, C., Kim, K., & Lee, J. Y. (2015). Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret. Virology, 481, 136–141. https://doi.org/10.1016/j.virol.2015.02.042

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free