Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.
Giebel, B., & Wodarz, A. (2006, February 7). Tumor suppressors: Control of signaling by endocytosis. Current Biology. https://doi.org/10.1016/j.cub.2006.01.022