Molecular iodine as a mild catalyst for cross-coupling of alkenes and alcohols

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Abstract

C-C bond formation is one of the most fundamental approaches toward molecular diversity in organic synthesis. In pursuit of environmentally friendlier chemical approaches to organic chemistry, we present a new metal-free method for direct dehydrative cross-coupling of alcohols and alkenes using molecular iodine as a Lewis acid catalyst under solvent-free reaction conditions. The reaction is atom-economical, tolerant to air and allows simple synthetic procedure, furnishing Csp3-Csp2 coupling products with yields up to 97%. The method has proved efficient for coupling of secondary benzyl alcohols with phenyl-substituted alkenes.

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Čebular, K., & Stavber, S. (2018). Molecular iodine as a mild catalyst for cross-coupling of alkenes and alcohols. In Pure and Applied Chemistry (Vol. 90, pp. 377–386). Walter de Gruyter GmbH. https://doi.org/10.1515/pac-2017-0414

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