Natural history and epidemiology of benign prostatic hyperplasia

Abstract

Benign prostatic hyperplasia (BPH) is a common benign tumor that develops in men and is bothersome in elderly patients. The prevalence of lower urinary tract symptoms in the general population increases with aging. The normal prostate weighs 20±6g in menaged 21-30 years. The prevalence of pathological BPH is only 8% at the 4th decade of life; however,50% of the male population develop pathological BPH at age 51-60 years. The average weight of a prostate that is recognized at autopsy as having BPH is 33±16g. Men aged 70-79 years are 4.6 times more likely (95% confidence interval, 2.1-10.1) than those aged 40-49 years to have sought health care because of urinary symptoms. Health care-seeking behavior is influenced by BPH-related symptoms severity, particularly if the symptoms are bothersome and interfere with a patient's daily activities. The progression of BPH is observed in terms of increased prostate volume and decreased maximal urinary flow rate. In addition, disease progression increase the risk of acute urinary retention and surgery. On average, the international prostate symptom score increases 0.18 points/yr, maximal urinary flow rate decreases by 2%/yr, and median prostate growth increases 1.9%/yr for BPH. In addition, the accumulative incidence of acute urinary retention is 2.7%. BPH itself is associated with a deteriorated clinical and symptomatic natural history, and early treatment may benefit patients with bothersome symptoms of BPH.