Advances in Imaging in Age-Related Macular Degeneration

Abstract

Age-related macular degeneration (AMD) is the leading cause of severe visual loss in people aged 50 years or older in the developed world. Advances in ocular imaging have driven many of the major breakthroughs in our understanding of the disease’s pathogenesis, as well as many improvements in diagnosis and treatment. In this review, we describe the latest advances in ocular imaging applicable to patients with AMD. We begin with an overview of topographic imaging techniques, with an emphasis on emerging technologies such as ultrawidefield imaging, fundus autofluorescence, and adaptive optics. We next describe the latest advances in optical coherence tomography imaging, with an emphasis on novel image acquisition and analysis techniques of use for patients with AMD. In both cases, we describe the current state of the art for clinical imaging of patients with AMD and highlight new approaches likely to appear in clinical settings in the near future.