GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage

51Citations
Citations of this article
114Readers
Mendeley users who have this article in their library.

Your institution provides access to this article.

Abstract

Intraepithelial lymphocytes (IELs) of the small intestine are intimately associated with the epithelial cells. Yet, the factors controlling their migration and interaction dynamics are poorly understood. We demonstrate that GPR55, a receptor that mediates migration inhibition in response to lysophosphatidylinositol (LPI), negatively regulates T cell receptor (TCR) IEL accumulation in the small intestine. Intravital imaging studies show that GPR55-deficient IELs migrate faster and interact more extensively with epithelial cells. GPR55 also negatively regulates T cell homing to the small intestine and T cell egress from Peyer’s patches. GPR55 deficiency or short-term antagonist treatment protects from nonsteroidal anti-inflammatory drug–induced increases in intestinal permeability. These findings identify a migration-inhibitory receptor that restrains IEL–epithelial cell cross-talk and show that antagonism of this receptor can protect from intestinal barrier dysfunction.

Cite

CITATION STYLE

APA

Sumida, H., Lu, E., Chen, H., Yang, Q., Mackie, K., & Cyster, J. G. (2017). GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage. Science Immunology, 2(18). https://doi.org/10.1126/sciimmunol.aao1135

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free