Recently, 5-hydroxy-L-tryptophan (5-OHTrp) has been promoted as an alternative to banned L-tryptophan as a dietary supplement. It has been claimed to help alleviate obesity, insomnia, depression, and headaches. However, eosinophilia-myalgia syndrome (EMS)-like symptoms have also been associated with ingestion or exposure to 5-OHTrp. HPLC-UV analysis of EMS-implicated 5-OHTrp revealed the presence of peak X. described as case-implicated. We show that peak X is actually a family of contaminants with the same molecular weight (234 Da) and similar HPLC retention times. We also demonstrate that all eight samples of commercially available 5-OHTrp analyzed by HPLC-MS contained three or more contaminants of the peak X family. The significance of these findings is discussed.
CITATION STYLE
Klarskov, K., Johnson, K. L., Benson, L. M., Gleich, G. J., & Naylor, S. (2000). Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. In Advances in Experimental Medicine and Biology (Vol. 467, pp. 461–468). https://doi.org/10.1007/978-1-4615-4709-9_58
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