Comparison of the genomic profile of cancer stem cells and their non-stem counterpart: The case of ovarian cancer

9Citations
Citations of this article
24Readers
Mendeley users who have this article in their library.

Abstract

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.

Cite

CITATION STYLE

APA

Mazzoldi, E. L., Pastò, A., Pilotto, G., Minuzzo, S., Piga, I., Palumbo, P., … Indraccolo, S. (2020, February 1). Comparison of the genomic profile of cancer stem cells and their non-stem counterpart: The case of ovarian cancer. Journal of Clinical Medicine. MDPI. https://doi.org/10.3390/jcm9020368

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free