Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents

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Abstract

A screening of marine bacteria for antimicrobial activity resulted in the isolation of Bacillus pumilus (SP21) from a sediment sample collected in the Bahamas. A bioassayguided fractionation led to the isolation of five surfactin analogs, glycocholic acid, amicoumacins A and B in addition to three new compounds named lipoamides A-C. The chemical structure of all the bioactive compounds was elucidated using spectroscopic methods including 2D NMR and MS. The antimicrobial activity of each compound was evaluated against a panel of pathogens and is reported herein.

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Berrue, F., Ibrahim, A., Boland, P., & Kerr, R. G. (2009). Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents. In Pure and Applied Chemistry (Vol. 81, pp. 1027–1031). https://doi.org/10.1351/PAC-CON-08-09-25

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