Abstract
Neural differentiation is a complex process that requires highly accurate spatial and temporal regulation by extracellular and intracellular programs. Epigenetic mechanisms, such as DNA methylation, covalent histone posttranscriptional modifications, chromatin organization, and noncoding regulatory RNA, are key regulators of pluripotency maintenance and differentiation. The misregulation of these mechanisms could lead to neurological diseases and cancer.
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Toranõ, E. G., Fernandez, A. F., Urdinguio, R. G., & Fraga, M. F. (2014). Role of epigenetics in neural differentiation: Implications for health and disease. In Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health (pp. 63–79). Springer New York. https://doi.org/10.1007/978-1-4939-0706-9_2
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