Abstract
Protein tyrosine nitration is an important posttranslational modification involving a variety of diseases. It's occurred via peroxynitrite or nitrite/hydrogen peroxide/hemeperoxydase system, and nitrotyrosine is formed by free radical reaction. The in vivo protein nitration pathways, the mechanism and the biological significance are discussed. It points out that protein nitration has selectivity, and nitration of special tyrosine residue(s) can lead to the alteration of the structure and functions of the protein, and affect the immunological response or signal transduction involved.
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Chi, Q., & Huang, K. (2006). Protein tyrosine nitration. Progress in Chemistry, 18(7–8), 1019–1025. https://doi.org/10.4161/psb.4.10.9466
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