Effects of HCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum

Abstract

HCG or human pituitary LH was administered to normal women during the luteal phase of the menstrual cycle. Functional activity of the corpora lutea was assessed by measurements of plasma progestogen levels by a competitive protein binding method. Both HCG and LH treatment produced significant elevations in progestogen levels. Levels in treatment cycles were 2-3 times those observed in control cycles. The interval between menses was lengthened 6, 7 and 9 days in the 3 HCG-treated women and 3, 7 and 8 days in the LH-treated women. These data suggest that both LH and HCG are capable of stimulating progesterone synthesis in a normal corpus luteum in vivo. © 1971 by The Endocrine Society.