A novel porcine collagen-based paste dermal substitute to treat full-thickness wounds has been investigated. A thin split-thickness skin graft or autologous cultured keratinocytes have been combined with dermal replacement biomaterial and applied to full-thickness wounds in a porcine wound chamber preclinical experimental model. The data obtained suggest that: (1) dermal substitute biomaterials may improve wound re-epithelialisation when combined with cultured autologous keratinocytes and (2) porcine collagen paste is able to support split-thickness skin graft survival as well as autologous cultured keratinocyte proliferation. These results demonstrate that the novel porcine collagen paste has a potential as a dermal substitute to treat acute full-thickness wounds and an application for the burns emergency care treatment. © 2011 Springer Science+Business Media B.V.
CITATION STYLE
Shevchenko, R. V., Sibbons, P. D., Sharpe, J. R., & James, S. E. (2011). A novel skin substitute biomaterial to treat full-thickness wounds in a burns emergency care. NATO Science for Peace and Security Series A: Chemistry and Biology, 247–255. https://doi.org/10.1007/978-94-007-0217-2_25
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