Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells

N/ACitations
Citations of this article
25Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Processing of mutagenic DNA damages by the double strand breaks (DSB) in eukaryotes is most likely achieved by multiple pathways, including homologous recombination. Although RAD52 has been shown to be important for DSB repair in yeasts, its role in DSB repair in mammalian cells has not been demonstrated. This study reports for the first time that the overexpression of human RAD52 confers enhanced resistance to γ-rays and induces homologous intrachromosomal recombination in cultured monkey cells. Recombination frequency synergistically increased by the combination of overexpression of RAD52 and ionizing radiation. These observations suggest that homologous recombination mediated by RAD52 is involved in double-stranded break repair in mammalian cells.

Cite

CITATION STYLE

APA

Park, M. S. (1995). Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells. Journal of Biological Chemistry, 270(26), 15467–15470. https://doi.org/10.1074/jbc.270.26.15467

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free