Asymptotic analysis of an advection-dominated chemotaxis model in multiple spatial dimensions

Abstract

This paper is devoted to a study of the asymptotic behavior of solutions of a chemotaxis model with logistic terms in multiple spatial dimensions. Of particular interest is the practically relevant case of small diffusivity, where (as in the one-dimensional case) the cell densities form plateau-like solutions for large time. The major difference from the one-dimensional case is the motion of these plateau-like solutions. with respect to the plateau boundaries separating zero density regions from maximum density regions. This interface motion appears on a non-logarithmic time scale and can be interpreted as a surface diffusion law. The biological interpretation of the surface diffusion is that a packed region of cells can change its shape mainly if cells diffuse along its boundary. The theoretical results on the asymptotic behavior are supplemented by several numerical simulations on two- and three-dimensional domains. © 2008 International Press.