How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression. © 2008 Elsevier Inc. All rights reserved.
Blackwell, T. K., & Walker, A. K. (2008, October 3). OMA-Gosh, Where’s that TAF? Cell. https://doi.org/10.1016/j.cell.2008.09.021