Dementia-Associated Compulsive Singing (DACS): Presentation of Unpublished Clinical Cases Miniseries

0Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Dementia-associated compulsive singing (DACS) is a neurotransmettitorial-based behavioral disturbance, characterized by an unabating melodic expression, occurring in patients that suffer from evolved dementia. Previously described only as a “punding” aspect of the dopamine dysregulation syndrome (DDS) in the Parkinson’s disease (PD), compulsive singing has now been described, for the first time, in four non-PD patients effectively treated with Haloperidol or Quetiapine. Unlike the DDS-associated conditions, in our cases DACS is not pharmacologically induced, being that all patients were L-dopa-free. We detected a diffuse hyperintensity of the white matter and brain atrophy, with insular shrinkage as well as ventricular system and/or sub-arachnoid space enlargement in our DACS patients. Furthermore, similarly to the other behavioral symptoms of dementia, DACS also seems to be correlated to the degree of cognitive and functional impairment, rather than its subtype. In conclusion, DACS is a non-cognitive, unpublished clinical aspect of evolved dementia, which is interesting due to the involvement of the extra-nigral dopaminergic system, resulting in an unabating altered behavior, but also to the enrichment of our knowledge in the involutional diseases of the central nervous system and their physiopathological manifestations.

Cite

CITATION STYLE

APA

De Masi, R., Orlando, S., & Costa, M. C. (2022). Dementia-Associated Compulsive Singing (DACS): Presentation of Unpublished Clinical Cases Miniseries. International Journal of Environmental Research and Public Health, 19(17). https://doi.org/10.3390/ijerph191710844

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free