Gentamicin in Combination with Ascorbic Acid Regulates the severity of Staphylococcus aureus Infection-Induced Septic Arthritis in Mice

42Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

To study the effects of gentamicin in combination with ascorbic acid on septic arthritis, mice were infected with Staphylococcus aureus (S. aureus) and treated with gentamicin, which was given at 5 mg/kg after 24 h of infection, followed by ascorbic acid, given at 20 mg/kg body weight after 2 h of gentamicin treatment. Mice were sacrificed at 3, 9, 15 days post-infection (dpi). Combined treatment of infected mice with gentamicin and ascorbic acid eradicated the bacteria from the blood, spleen and synovial tissue and showed a significant gross reduction in arthritis, reduced serum levels of tumour necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). S. aureus-infected mice have demonstrated the disturbed antioxidant status measured in terms of cellular antioxidants like reduced glutathione and antioxidant enzymes such as superoxide dismutase (SOD) and catalase. The same were ameliorated when the animals were co-treated with gentamicin along with ascorbic acid. © 2012 Blackwell Publishing Ltd.

Cite

CITATION STYLE

APA

Mal, P., Dutta, S., Bandyopadhyay, D., Dutta, K., Basu, A., & Bishayi, B. (2012). Gentamicin in Combination with Ascorbic Acid Regulates the severity of Staphylococcus aureus Infection-Induced Septic Arthritis in Mice. Scandinavian Journal of Immunology, 76(6), 528–540. https://doi.org/10.1111/j.1365-3083.2012.02766.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free