Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy

Abstract

This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease (PD), a prevalent non-motor symptom contributing significantly to patients’ morbidity. A marked alteration in the gut microbiota, predominantly an increase in the abundance of Proteobacteria and Bacteroidetes, is observed in PD-related constipation. Conventional treatments, although safe, have failed to effectively alleviate symptoms, thereby necessitating the development of novel therapeutic strategies. Microbiological interventions such as prebiotics, probiotics, and fecal microbiota transplantation (FMT) hold therapeutic potential. While prebiotics improve bowel movements, probiotics are effective in enhancing stool consistency and alleviating abdominal discomfort. FMT shows potential for significantly alleviating constipation symptoms by restoring gut microbiota balance in patients with PD. Despite promising developments, the causal relationship between changes in gut microbiota and PDrelated constipation remains elusive, highlighting the need for further research in this expanding field.