Diabetes screening: Detection and application of saliva 1,5-anhydroglucitol by liquid chromatography-mass spectrometry

Abstract

Context: Unlike other commonly used invasive blood glucose-monitoring methods, salivadetection prevents patients from suffering physical uneasiness. However, there are few studieson saliva 1,5-anhydroglucitol (1,5-AG) in patients with diabetes mellitus (DM).Objective: This study aimed to evaluate the effectiveness of saliva 1,5-AG in diabetes screeningin a Chinese population.Design and Participants: This was a population-based cross-sectional study. A total of 641subjects without a valid diabetic history were recruited from September 2018 to June 2019.Saliva 1,5-AG was measured with liquid chromatography-mass spectrometry.Main outcome measures: DM was defined per American Diabetes Association criteria. Theefficiency of saliva 1,5-AG for diabetes screening was analyzed by receiver operating characteristiccurves, and the optimal cutoff point was determined according to the Youden index.Results: Saliva 1,5-AG levels in subjects with DM were lower than those in subjects who didnot have DM (both P