High-frequency oscillatory ventilation in children: A 10-year experience

9Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

Objectives: The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. Methods: This was a retrospective observational cohort study of children ventilated by HFOV between January, 2002 and December, 2011. The following parameters were recorded: demographic and clinical data, and blood gases and ventilatory parameters during the first 48 hours of HFOV. Results: 80 children were included, with a median age of 1.5 months (min: one week; max: 36 months). Pneumonia (n = 50; 62.5%) and bronchiolitis (n = 18; 22.5%) were the main diagnoses. Approximately 40% (n = 32) of the patients developed acute respiratory distress syndrome (ARDS). Conventional mechanical ventilation was used in 68 (85%) of patients prior to HFOV. All patients who started HFOV had hypoxemia, and 56 (70%) also presented persistent hypercapnia. Two hours after starting HFOV, a significant improvement in SatO2/FiO2 ratio (128 ± 0.63 vs. 163 ± 0.72; p < 0.001) that was sustained up to 24 hours of HFOV and a decrease in FiO2 were observed. Since the beginning of HFOV, the mean PCO2 significantly decreased (87 ± 33 vs. 66 ± 25; p < 0.001), and the pH significantly improved (7.21 ± 0.17 vs. 7.32 ± 0.15; p < 0.001). Overall survival was 83.8%. Conclusions: HFOV enabled an improvement in hypercapnia and oxygenation. It is a safe option for the treatment of ARDS and severe small airway diseases. Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

Cite

CITATION STYLE

APA

Moniz, M., Silvestre, C., Nunes, P., Abadesso, C., Matias, E., Loureiro, H., & Almeida, H. (2013). High-frequency oscillatory ventilation in children: A 10-year experience. Jornal de Pediatria, 89(1), 48–55. https://doi.org/10.1016/j.jped.2013.02.008

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free