Steroid-Sensitive Nephrotic Syndrome

Abstract

Nephrotic syndrome is among the most common chronic kidney diseases of childhood. The condition is primary or idiopathic in more than 90% cases. Therapy with prednisone results in complete remission of proteinuria in ~90% patients, termed steroid-sensitive nephrotic syndrome (SSNS). Approximately, 70% patients with SSNS relapse, and about 50% show frequent relapses or steroid dependence that requires careful therapy with steroid sparing agents. The aim of this therapy is to prevent complications of the disease and minimize the side effects of corticosteroids and other medications. SSNS is a self-limiting illness with majority of patients outgrowing the disease by puberty. However, a small but significant proportion of patients show persistence of the illness into adulthood.