Dosage and administration length of Centella asiatica (L.) urban decrease the level of sod and mda and improve brain histological condition of rats

Abstract

Medicinal plants have been used for treating many kinds of illness due to their safety, cheap and easy to be accessed by all level of society. This study was aimed to determine the effect of the dosage forms (fresh, boiled and ethanol extracted) and the duration (24 and 42 days) of medicinal plant Centella asiatica to the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and the histopathology of diabetic rat brain. The results showed that administration of various dosage forms of C. asiatica were able to increase the number of pyramid cells and neuroglia in the cerebrum significantly (P <0.01) but had no significant effect (P>0.01) at the administration length and the interaction between both treatments. This finding resulted in the new traditional herbal medicine that can be used for treating degenerative disorders on nervous system.