Systemic Therapies for Patients with Metastatic Spinal Disease

Abstract

Spinal metastasis is a common condition in metastatic cancer patients and may lead to debilitating neurological dysfunction and pain if left unaddressed. Comprehensive assessment and management involves a multidisciplinary team consisting of neurological surgeons, radiation oncologists, medical oncologists, and other specialties. Herein, we review the role of systemic anticancer therapies in the management of metastatic spinal disease. We also discuss the most recent data on the effects of systemic therapies on bone-specific and general clinical outcomes in patients with spinal metastases.