Peptides mimicked from active site of promiscuous aldo-ketoreductase were synthesized and tested as asymmetry catalysts in the Michael adduct reaction of aldehydes or ketones with nitroolefins to furnish the corresponding c-nitroaldehydes, γ-nitroketones with up to 93 % yield, 99:1 dr and 71 % ee at room temperature and on eco-friendly solvents. Aspartic acid residue as second amino acid produced greater enantioselectivity. © Springer Science+Business Media New York 2013.
CITATION STYLE
Bayat, S., Tejo, B. A., Salleh, A. B., Abdulmalek, E., Normi, Y. M., & Abdul Rahman, M. B. (2014). Asymmetric michael reaction catalyzed by mimicked peptides. Catalysis Letters, 144(2), 222–228. https://doi.org/10.1007/s10562-013-1156-6
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