Atopic dermatitis (AD) is a common disease of childhood, and some patients experience a prolonged clinical course into adolescence and adulthood. Systemic management is required when AD is not adequately controlled with topical medications. Our aim is to provide a comprehensive review of commonly used systemic immunomodulating agents in childhood and adult AD, including cyclosporine A (CsA), azathioprine (AZA), methotrexate (MTX) and mycophenolate mofetil (MMF), which are prescribed off-label in the United States, as well as dupilumab, an FDA-approved biologic. We will also provide a brief overview of emerging systemic therapies currently under investigation.
CITATION STYLE
Davari, D. R., Nieman, E. L., McShane, D. B., & Morrell, D. S. (2021). Current perspectives on the systemic management of atopic dermatitis. Journal of Asthma and Allergy, 14, 595–607. https://doi.org/10.2147/JAA.S287638
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