Do Interictal Rates Influence Treatment Outcomes in Temporal Lobe Epilepsy?

Abstract

Quantitative Electrocorticographic Biomarkers of Clinical Outcomes in Mesial Temporal Lobe Epileptic Patients Treated With the RNS System Desai N, Tchen T, Morrell MJ. Clinical Neurophysiology. 2019;130:1364-1374. doi:10.1016/j.clinph.2019.05.017. OBJECTIVES: Find interictal electrocorticographic (ECoG) biomarkers of clinical outcomes in mesiotemporal lobe (MTL) epilepsy patients. METHODS: In the NeuroPace RNS System clinical trials with 256 patients, 20 MTL patients with the most reduction in clinical seizures at year 7 compared to baseline (upper response quartile: 96.5% median change) and 20 with the least reduction in clinical seizures (lower response quartile: 17.4% median change) were evaluated. Clinical and interictal ECoG features from the 2 response quartiles were compared. RESULTS: Demographic and clinical features were similar in the upper and lower response quartiles. Interictal spike rate (ISR) was substantially lower (P 25 Hz) were also different (P