Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design

Abstract

Structure-based clustering technique is useful for identifying superfamilies of major histocompatibility complex (MHC) proteins with similar binding specificities. The resolved MHC superfamilies play an important role in vaccine development, from discovering new targets for broad-based vaccines and therapeutics to optimizing the affinity and selectivity of hits. Here, we describe a protocol and provide a summary for grouping MHC proteins according to their structural interaction characteristics. © Springer Science+Business Media New York 2014.