Current update on combined hepatocellular-cholangiocarcinoma

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Abstract

Combined hepatocellular-cholangiocarcinoma is a rare but unique primary hepatic tumor with characteristic histology and tumor biology.Recent development in genetics and molecular biology support the fact that combined hepatocellular-cholangiocarcinoma is closely linked withcholangiocarcinoma, rather than hepatocellular carcinoma. Combined hepatocellular cholangiocarcinoma tends to present with an more aggressive behavior and a poorer prognosis than either hepatocellularcarcinoma or cholangiocarcinoma. An accurate preoperative diagnosis and aggressive treatment planning can play crucial roles in appropriate patientmanagement.

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Maximin, S., Ganeshan, D. M., Shanbhogue, A. K., Dighe, M. K., Yeh, M. M., Kolokythas, O., … Lalwani, N. (2014). Current update on combined hepatocellular-cholangiocarcinoma. European Journal of Radiology Open. Elsevier Ltd. https://doi.org/10.1016/j.ejro.2014.07.001

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