Combined hepatocellular-cholangiocarcinoma is a rare but unique primary hepatic tumor with characteristic histology and tumor biology.Recent development in genetics and molecular biology support the fact that combined hepatocellular-cholangiocarcinoma is closely linked withcholangiocarcinoma, rather than hepatocellular carcinoma. Combined hepatocellular cholangiocarcinoma tends to present with an more aggressive behavior and a poorer prognosis than either hepatocellularcarcinoma or cholangiocarcinoma. An accurate preoperative diagnosis and aggressive treatment planning can play crucial roles in appropriate patientmanagement.
Maximin, S., Ganeshan, D. M., Shanbhogue, A. K., Dighe, M. K., Yeh, M. M., Kolokythas, O., … Lalwani, N. (2014). Current update on combined hepatocellular-cholangiocarcinoma. European Journal of Radiology Open. Elsevier Ltd. https://doi.org/10.1016/j.ejro.2014.07.001