NaAlg-PVA-g-AAm/ZnO nanocomposite hydrogel as material of wound dressing: Synthesis and characterization

Abstract

In this study, sodium alginate and polyvinyl alcohol grafted acrylamide with modified ZnO nanoparticles to nanocomposite hydrogel NaAlg-PVA-g-AAm/ZnO have been successfully synthesized. The characterizations of hydrogels were supported by Fourier Transform Infrared (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Tunneling Electron Microscopy and Energy Dispersive X-Ray (TEM-EDX). The image of TEM obtained shows that ZnO nanoparticle are distributed evenly with about 70 nm diameter in hydrogel nanocomposite. The results for NaAlg-PVA-g-AAm nanocomposite hydrogel modified ZnO nanoparticles was obtained the best nanocomposite at 32.21 ppm Zn2+ concentration. It has Zn2+ ion maximum loading capacity at 80 %, maximum release capacity of 25 % measured by AAS, and its water maximum swelling capacity is 230.20 (g/g). While the maximum swelling capacity for NaAlg-PVA-g-AAm nanocomposite hydrogel is 106.30 (g/g). From in-vitro antibacterial activity test, S.aureus (gram positive bacteria) has more resistance than P. Aeruginosa (gram negative bacteria) in which S. aureus inhibition percentage is 60.22 % and P. Aeruginosa is 40.10 % with the minimum inhibitory concentration of 31.25 ppm.