Potassium fluoride/alumina mediated simple synthesis of Hantzsch 1, 4-dihydropyridines

Abstract

A general and practical technique to achieve synthesis of 1,4-dihydropyridines in excellent yields has been investigated using potassium fluoride/alumina (KF/Al2O3) as a solid base. The ammonia was obtained either from thermal decomposition of ammonium acetate or by passing ammonia gases in the form of bubbled through hetereogenous reaction medium using an apparatus.