We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that it can handle spectra from any instrument and fragmentation technique. We demonstrate the utility of the algorithm, and the power of multiple spectra, by showing that combining pairs of spectra (one CID and one ETD) greatly improves de novo sequencing success rates. © 2008 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Datta, R., & Bern, M. (2008). Spectrum fusion: Using multiple mass spectra for de novo peptide sequencing. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4955 LNBI, pp. 140–153). https://doi.org/10.1007/978-3-540-78839-3_13
Mendeley helps you to discover research relevant for your work.