Mechanistic considerations in the development and use of azine, diazine and azole N-oxides in palladium-catalyzed direct arylation.

Abstract

Azines, diazines or thiazole N-oxides are highly reactive substrates in palladium-catalyzed direct arylation reaction. For these reactions, the results are inconsistent with an SEAr reaction pathway and may best fit with a concerted metalation-deprotonation-like (CMD) mechanism.